Why Use Miniature Swine in Dermal Research?
Brown, L., Liu, J., Madsen, T., Lawson, C., Blair, E., Bouchard, G.F.
Swine have been used extensively in dermal research because of the similarities of the integument to humans. Miniature swine offer many distinct advantages for dermal research. Skin researchers require efficient animal models which are predictive of human responses. Pig skin is anatomically, physiologically, biochemically and immunologically similar to human skin, and the skin is ‘fixed skin’ like humans. Pig skin mirrors human skin in having a sparse haircoat, a relatively thick epidermis, similar epidermal turnover kinetics, lipid composition and carbohydrate biochemistry, lipid biophysical properties, and a similar arrangement of dermal collagen and elastic fibers. Porcine or miniature swine models offer significant advantages and have a record of predicting treatment modalities in humans over alternate. Included uses are models for malignant melanoma, wound healing (including delayed diabetic model), phototoxicity, dermal toxicology, dermal PK/TK, iontophoresis, dermal irritation, thermal injury, contact allergic dermatitis, depigmentation, and chemical vesication. These dermal study types will be briefly described and aspects of studies in miniature swine will be discussed. Miniature swine models provide useful safety and efficacy data for novel cutaneoustherapy product development. Miniature swine offer researchers unique tools in dermal research.