Surgically Produced Volume and Pressure Overload Heart Failure Models in Swine

Introduction

One of the most common uses of swine in biomedical research is their usage as models of cardiovascular diseases, which are the primary cause of death worldwide. pigs have become one of the favored models in this area of research due to their anatomic and physiologic characteristics which are similar to that of humans. Included in cardiac models would be cardiac surgery, ischemic heart disease (coronary artery disease), valvular disease, cardiomyopathy, volume overload models, and pressure overload models. These types of studies include preclinical testing of devices and vascular surgical procedures which have been discussed in other manuscripts on this website. This manuscript provides an overview of surgically produced models of heart failure caused by volume or pressure overload.

Authors

M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of SC, Charleston, SC 29425

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