Human melanoma is the fastest growing cancer currently in USA and worldwide. Melanoma accounts for 5% of all skin cancers but 71% of all skin cancer deaths. The risk for melanoma has steadly increased since 1935 when the risk was 1:1,500. Today one in 74 people are diagnosed with melanoma. The mechanism for melanoma initiation is unknown and no significant advances in medical therapies (survival) for patients with advanced melanoma have occurred in the past 30 years. Additional research and drug development are required. Miniswine offer insights into the genetics, immunology and pathogenesis of malignant melanoma.