Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically manipulated. Total diversion of the pancreatic secretions from the duodenum will result in dietary deficiencies and intestinal dysfunction within a week. Consequently, cannulation of the pancreatic duct is performed with caution and either the experiments are short term or the duct is cannulated in such a manner that at least a portion of the pancreatic secretions continue to flow into the duodenum. Replacement pancreatic enzymes may also be administered orally.
M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of SC, Charleston, SC 29425