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Dermal Toxicology Application Area Changes as Compared to Theoretical Total Surface Area of Hanford Miniature Swine Over 18 Weeks

Dermal Toxicology Application Area Changes as Compared to Theoretical Total Surface Area of Hanford Miniature Swine Over 18 Weeks

Mar 12, 2019 | Scientific Posters

Abstract Dermal toxicology studies are frequently initiated in growing animal models. The test compound is generally applied on a dermal application area (DAA) that is frequently set at certain ratio to total surface area. Since the growth during juvenile period can...
Comparative Cardiovascular Physiology & Pathology in Selected Lineages of Minipigs: Relation to Drug Safety Evaluation

Comparative Cardiovascular Physiology & Pathology in Selected Lineages of Minipigs: Relation to Drug Safety Evaluation

Jan 9, 2019 | White Papers

Introduction The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs...
The Importance of Minipigs in Dermal Safety Assessment: An Overview

The Importance of Minipigs in Dermal Safety Assessment: An Overview

May 6, 2018 | White Papers

Abstract The use of miniature swine as a non-rodent species in safety assessment has continued to expand for over a decade and their use has become routine, particularly in pharmacology as a model for human integumentary diseases. Translational preclinical swine study...
Sinclair Research Contributes to Recent Issue of Toxicologic Pathology

Sinclair Research Contributes to Recent Issue of Toxicologic Pathology

Jul 12, 2016 | News

Sinclair Research Center and Sinclair BioResources have recently contributed to a special issue of Toxicologic Pathology (Volume 44, Number 3, 2016) titled Swine in Translational Research and Drug Development. This issue focuses on the most recent developments of the...
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