May 3, 2019 | White Papers
Regulatory Dermal Toxicology Testing Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways....
Mar 28, 2019 | White Papers
Toxicology & Pharmacology Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs...
Mar 27, 2019 | White Papers
Porcine Integumentary System Models: Dermal Toxicology Introduction Swine have been used extensively in dermal research because of the similarities to humans. In the field of toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal...
Mar 26, 2019 | White Papers
Introduction Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature...
Mar 26, 2019 | White Papers
Introduction Minipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology studies. Acute, subchronic and chronic studies are possible using all routes of administration. Minipigs have distinct size advantages over domestic pigs. There...
Mar 26, 2019 | White Papers
Introduction The use of miniature swine as a nonrodent species in safety assessment has continued to expand for over a decade, and they are becoming routinely used in toxicology and in pharmacology as well as a model for human diseases. Miniature swine models...
Mar 26, 2019 | White Papers
Introduction A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current...
Mar 13, 2019 | Scientific Posters
Oral Cyclosporine A Immunosuppressive Therapy Leads to Systemic Toxicity in the Royal College of Surgeons Rats Abstract Male and female Royal College of Surgeons (RCS) rats were randomized into two balanced groups with or without cyclosporine A (CsA) in drinking water...
Mar 12, 2019 | Scientific Posters
Validation of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments Abstract Background: A functional observational battery (FOB) is recommended as the first tier neurotoxicity screening in the preclinical safety pharmacology...
Mar 12, 2019 | Scientific Posters
Comparative Sensitivity and Reliability of a Multi-Analytes Platform and a Multiplex Flow Cytometry in the Quantitation of Circulating Cytokines Level in a Mouse Model of Endotoxemia Abstract The objective of the study was to compare two different multiplex assay...
