Regulatory Dermal Toxicology Testing

Regulatory Dermal Toxicology Testing

Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways. Download this Scientific White...
Toxicology & Pharmacology

Toxicology & Pharmacology

Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs and non human primates as the...
Porcine Integumentary System Models: Dermal Toxicology

Porcine Integumentary System Models: Dermal Toxicology

Introduction Swine have been used extensively in dermal research because of the similarities to humans. In the field of  toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal absorption, phototoxicity, allergic contact dermatitis and...
Minipigs: Applications in Toxicology

Minipigs: Applications in Toxicology

Introduction Minipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology studies. Acute, subchronic and chronic studies are possible using all routes of administration. Minipigs have distinct size advantages over domestic pigs. There...