Bone Marrow Access in Swine

Bone Marrow Access in Swine

Introduction It may be necessary to perform bone marrow collection as part of an experimental protocol. For example the isolation of hematopoietic stem cells may require this methodology. It is also possible to administer therapeutic agents, such as fluids, and test...
MHC Defined Lineages for Transplantation

MHC Defined Lineages for Transplantation

Introduction Resource herds of swine leukocyte antigen (SLA)-characterized miniature pigs are an important tool for the study of immune responses and disease resistance. Miniature swine are valuable animal models for biomedical  research, such as transplantation. SLA...
Principles of Thoracic Surgery

Principles of Thoracic Surgery

Introduction Many experimental procedures involve thoracotomies because of the common usage of swine in cardiovascular research. The reasons for using swine in these types of studies are the similarities in anatomy and physiology which are shared with humans. Common...
Pain Control and Pain Research in Swine

Pain Control and Pain Research in Swine

Abstract There are two aspects to pain research in swine. The one of primary interest to research veterinarians is the control of pain associated with experimental procedures and the second is the use of swine as an animal model to study new agents and methods of...
Common Bile Duct Cannulation in Swine

Common Bile Duct Cannulation in Swine

Introduction Bile duct cannulation is most frequently performed to study hepatic metabolism and secretion of pharmaceuticals in swine. The bile duct must be cannulated in a re-entry fashion for experiments longer than a few days, otherwise pathology due to a lack of...
Catheterization of the Pancreatic Duct

Catheterization of the Pancreatic Duct

Abstract Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically manipulated. Total diversion of the...
Perioperative Care of Swine

Perioperative Care of Swine

Introduction Swine are widely used in protocols that involve anesthesia and invasive surgical procedures. In order to ensure proper recovery of animals, preoperative, intraoperative and postoperative techniques specific to the species need to be considered. This...
Hemorrhagic Shock Models in Swine

Hemorrhagic Shock Models in Swine

Introduction Swine have long been used as models for the study of hemorrhagic shock. In recent years there has been a resurgence of interest in the pathogenesis and treatment of hemorrhagic shock due to the ongoing conflicts associated with combating terrorism....