Mar 12, 2019 | Scientific Posters
Abstract Miniswine models have evolved to become very important in the preclinical evaluation of drugs. Moreover, translational medicine programs are confirming that the minipigis the model of choice for pharmacokinetics assessment, in addition to its role in the...
Mar 8, 2019 | Scientific Posters
Abstract The potency of human insulin has classically been evaluated in rabbits following the U.S. Pharmacopeia (USP) guideline. However, since insulin analogues are intentionally different there is a need for a bioassay to assess clinical specific activity (U) in...
Mar 8, 2019 | Scientific Posters
Abstract Sustained and controlled analgesia for animals involved in potentially painful procedures, such as surgery, is required for animal welfare and ethical considerations. Many analgesics are available to Laboratory Animal Veterinarians but the pharmacokinetic and...
Jan 9, 2019 | White Papers
Introduction The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs...
Jan 1, 2019 | White Papers
Introduction Formulation of nonclinical evaluations is a challenge, with the fundamental need to achieve multiples of the clinical exposure complicated by differences in species and routes of administration-specific tolerances, depending on concentrations, volumes,...
