May 3, 2019 | White Papers
Introduction Diabetes mellitus is occurring in epidemic proportions worldwide and it is estimated by the World Health Organization (WHO) and the American Diabetes Association (ADA)2 that 300 million persons will have the disease by 2025. Currently WHO and ADA classify...
May 3, 2019 | White Papers
Introduction Diabetes mellitus is the most common endocrine disorder of humans and Type 2 diabetes (T2D) is currently the 6th leading cause of death. Diabetes is characterized by abnormalities of carbohydrate and lipid metabolism and long-term complications including...
Mar 26, 2019 | White Papers
Introduction Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the PK...
Mar 14, 2019 | Scientific Posters
Abstract Diabetes mellitus is an epidemic which is increasing in prevalence worldwide, especially in children. Two main types of diabetes are recognized: Type 1 (juvenile onset or insulin-dependent) and Type 2 (adult onset or non-insulin-dependent) and miniature swine...
Mar 13, 2019 | Scientific Posters
Abstract The purpose of this project was to develop a model of glaucoma via surgical induction of increased intraocular pressure (IOP) in Yucatan miniature swine. Three pigs (two female, one male) had bilateral IOP measurements performed prior to surgical intervention...
Mar 13, 2019 | Scientific Posters
Abstract Renal complications as a consequence of chronic diabetes is considered a leading cause of chronic kidney diseases in humans and it is currently estimated that diabetic nephropathy is affecting more than 7 million people in the U.S.Objective: Assess kidney...
Mar 13, 2019 | Scientific Posters
Abstract Pharmacodynamic effects on glycemia from various marketed insulins with known properties in humans were studied in the Yucatan miniature swine for comparative purposes. Yucatan miniature swine (Susscrofa, at least 3 months, 20-60 kg) were made diabetic with...
Mar 8, 2019 | Scientific Posters
Abstract The potency of human insulin has classically been evaluated in rabbits following the U.S. Pharmacopeia (USP) guideline. However, since insulin analogues are intentionally different there is a need for a bioassay to assess clinical specific activity (U) in...
Mar 8, 2019 | Scientific Posters
Abstract Cataracts as a consequence of chronic diabetes is considered a leading cause of legal blindness in humans in the United States and is also observed frequently in aged diabetic populations (>65%). Objective: Assess post-induction (PI) onset of clinical...
Mar 8, 2019 | Scientific Posters
Abstract Abundant evidence shows that patients with type 1 diabetes are at high risk for several cardiovascular disorders. Our objective was to assess potential cardiac electro-pathophysiology changes linked to chronic insulin-dependent diabetes in the Yucatan...
