May 3, 2019 | White Papers
Diabetes Mellitus and the Cardiometabolic Syndrome in Swine Introduction Diabetes mellitus is occurring in epidemic proportions worldwide and it is estimated by the World Health Organization (WHO) and the American Diabetes Association (ADA)2 that 300 million persons...
May 3, 2019 | White Papers
Diabetes in Miniature Swine Introduction Diabetes mellitus is the most common endocrine disorder of humans and Type 2 diabetes (T2D) is currently the 6th leading cause of death. Diabetes is characterized by abnormalities of carbohydrate and lipid metabolism and...
Mar 26, 2019 | White Papers
Introduction Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the PK...
Mar 14, 2019 | Scientific Posters
Blood Glucose (bG) Profiles Following IVGTT in Two Miniature Swine Lineages Abstract Diabetes mellitus is an epidemic which is increasing in prevalence worldwide, especially in children. Two main types of diabetes are recognized: Type 1 (juvenile onset or...
Mar 13, 2019 | Scientific Posters
Yucatan Miniature Swine Surgical Glaucoma Model Development and Response to Therapy Abstract The purpose of this project was to develop a model of glaucoma via surgical induction of increased intraocular pressure (IOP) in Yucatan miniature swine. Three pigs (two...
Mar 13, 2019 | Scientific Posters
Renal Complications in Chronic Diabetic Minipigs Abstract Renal complications as a consequence of chronic diabetes is considered a leading cause of chronic kidney diseases in humans and it is currently estimated that diabetic nephropathy is affecting more than 7...
Mar 13, 2019 | Scientific Posters
Pharmacodynamic Glycemia Effects from Rapid and Long-Acting Insulins Administered at Mealtime to Alloxan-Induced Diabetic Miniature Yucatan Swine Abstract Pharmacodynamic effects on glycemia from various marketed insulins with known properties in humans were studied...
Mar 8, 2019 | Scientific Posters
Comparison of the Rabbit, Diabetic Miniature Swine and Non-Human Primate to Evaluate the Clinical Biopotency of Insulin Products Abstract The potency of human insulin has classically been evaluated in rabbits following the U.S. Pharmacopeia (USP) guideline. However,...
Mar 8, 2019 | Scientific Posters
Prevalence and Incidence of Cataracts in a Population of Diabetic Yucatan Miniswine Abstract Cataracts as a consequence of chronic diabetes is considered a leading cause of legal blindness in humans in the United States and is also observed frequently in aged...
Mar 8, 2019 | Scientific Posters
Electrophysiological Assessment of Cardiac Complications in Chronic Diabetic Minipigs Abstract Abundant evidence shows that patients with type 1 diabetes are at high risk for several cardiovascular disorders. Our objective was to assess potential cardiac...
