Mar 13, 2019 | Scientific Posters
Abstract Purpose: To characterize transdermal pharmacokinetics of a ketoprofen cream formulation in the Sinclair and Gӧttingen strains of minipigs. Methods: Sinclair and Gӧttingen minipigs (3 per gender of each strain) were used in this study. Four mL of...
Mar 13, 2019 | Scientific Posters
Abstract Miniature swine are a recognized predictive model for human drug candidate dermatopharmacology studies. Tape stripping is a simple and effective method for removing the stratum corneum(SC) and is commonly employed during in vivo studies investigating the...
Mar 13, 2019 | Scientific Posters
Abstract Background/Purpose: This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine. Methods: For threshold erythema determinations, the UVR...
Mar 13, 2019 | Scientific Posters
Abstract Introduction: Skin is the largest organ in the body. Animals have skin which is generally similar to human skin, however, species specific anatomical and biochemical differences exist. The integument of animal models may vary in skin surface topography,...
Mar 13, 2019 | Scientific Posters
Abstract Dermatology is an extremely important field as the skin of humans and animals plays a life sparing protective role. The skin is the largest organ of the body and is metabolically active. Skin is constantly undergoing changes of shedding and regeneration. Skin...
Mar 13, 2019 | Scientific Posters
Abstract Minipig skin is similar to humans, and is often used to assess irritation to topically applied products. Evidence suggests Minoxidil is effective in enhancing hair growth in mice, but the effects of Minoxidil on hair growth in the minipig has not been...
Mar 12, 2019 | Scientific Posters
Abstract Our objective was to obtain quantitative data regarding the relationships between wound healing rates vs. initial size and shape of full thickness wounds. Each of 3 adult male Yucatan miniature swine had 9 full-thickness paraspinous wounds created. The wounds...
Mar 12, 2019 | Scientific Posters
Abstract Dermal toxicology studies are frequently initiated in growing animal models. The test compound is generally applied on a dermal application area (DAA) that is frequently set at certain ratio to total surface area. Since the growth during juvenile period can...
Mar 12, 2019 | Scientific Posters
Abstract Swine have been used extensively in dermal research because of the similarities of the integument to humans. Miniature swine offer many distinct advantages for dermal research. Skin researchers require efficient animal models which are predictive of human...
Mar 8, 2019 | Scientific Posters
Abstract Atopic Dermatitis is a common skin condition that clinically presents as erythematic, dry, pruritic skin. Minipigs are used frequently for toxicity/safety of dermally applied products, and thus a model of AD in minipigs would be beneficial for pre-clinical...
