May 3, 2019 | White Papers
Regulatory Dermal Toxicology Testing Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways....
May 3, 2019 | White Papers
White Hairless Miniature Swine Model for Dermal Studies Introduction The miniature swine is a well recognized animal model of dermal toxicology, transdermal drug delivery and woundhealing. In fact, staff members of the USFDA have recommended the use of miniature swine...
Mar 29, 2019 | White Papers
Sinclair – A Center of Excellence for Dermal Research Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal...
Mar 29, 2019 | Scientific Posters
Development of a Model of Dermal Inflammation and Irritation (Urticaria) in the Miniature Swine Abstract Histamine, the major mediator of mast cells, is known to induce a short-lived urticaria when applied intradermally in humans. The objective of this study is to...
Mar 29, 2019 | White Papers
Porcine Integumentary System Models: Wound Healing Introduction Swine have been a standard model for wound healing for many decades. This manuscript provides an overview of the models that may be utilized for studying wound healing, closure techniques, wound...
Mar 27, 2019 | White Papers
Porcine Integumentary System Models: Dermal Toxicology Introduction Swine have been used extensively in dermal research because of the similarities to humans. In the field of toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal...
Mar 26, 2019 | White Papers
Abstract Background/Purpose: This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine. Methods: For threshold erythema determinations, the UVR...
Mar 25, 2019 | White Papers
Abstract The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are...
Mar 25, 2019 | Scientific Posters
Comparison of Human, Porcine & Rodent Wound Healing with New Miniature Swine Study Data Abstract Accidental wounds are one of the most common reasons for human visits to hospital emergency services. Healthy individuals normally heal accidental skin wounds in a...
Mar 14, 2019 | Scientific Posters
Cutaneous Phototoxicity in White Hanford Miniature Swine Abstract Phototoxicology safety testing in the miniature swine provides a unique opportunity for risk assessment because of demonstrated similarities to human cutaneous anatomy and physiology. In addition, the...
