Regulatory Dermal Toxicology Testing

Regulatory Dermal Toxicology Testing

Regulatory Dermal Toxicology Testing Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways....
White Hairless Miniature Swine Model for Dermal Studies

White Hairless Miniature Swine Model for Dermal Studies

White Hairless Miniature Swine Model for Dermal Studies Introduction The miniature swine is a well recognized animal model of dermal toxicology, transdermal drug delivery and woundhealing. In fact, staff members of the USFDA have recommended the use of miniature swine...
Sinclair – A Center of Excellence for Dermal Research

Sinclair – A Center of Excellence for Dermal Research

Sinclair – A Center of Excellence for Dermal Research Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal...
Porcine Integumentary System Models: Wound Healing

Porcine Integumentary System Models: Wound Healing

Porcine Integumentary System Models: Wound Healing Introduction Swine have been a standard model for wound healing for many decades. This manuscript provides an overview of the models that may be utilized for studying wound healing, closure techniques, wound...
Porcine Integumentary System Models: Dermal Toxicology

Porcine Integumentary System Models: Dermal Toxicology

Porcine Integumentary System Models: Dermal Toxicology Introduction Swine have been used extensively in dermal research because of the similarities to humans. In the field of  toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal...
Miniature swine model of phototoxicity testing

Miniature swine model of phototoxicity testing

Abstract Background/Purpose: This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine. Methods: For threshold erythema determinations, the UVR...