May 3, 2019 | White Papers
Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways. Download this Scientific White...
May 3, 2019 | White Papers
Introduction The miniature swine is a well recognized animal model of dermal toxicology, transdermal drug delivery and woundhealing. In fact, staff members of the USFDA have recommended the use of miniature swine for dermal toxicological research and, until recently,...
Mar 29, 2019 | White Papers
Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal Research. This team works together to provide a wide range of...
Mar 29, 2019 | Scientific Posters
Abstract Histamine, the major mediator of mast cells, is known to induce a short-lived urticaria when applied intradermally in humans. The objective of this study is to develop a reproducible dermal urticaria model in miniature swine. Three female Hanford miniature...
Mar 29, 2019 | White Papers
Introduction Swine have been a standard model for wound healing for many decades. This manuscript provides an overview of the models that may be utilized for studying wound healing, closure techniques, wound treatments and bandaging.This manuscript is complementary to...
Mar 27, 2019 | White Papers
Introduction Swine have been used extensively in dermal research because of the similarities to humans. In the field of toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal absorption, phototoxicity, allergic contact dermatitis and...
Mar 26, 2019 | White Papers
Abstract Background/Purpose: This study determined the threshold doses for ‘solar erythema’ and for phototoxic responses to 8-methoxypsoralen (8-MOP) in white skin Hanford and grey skin Yucatan miniature swine. Methods: For threshold erythema determinations, the UVR...
Mar 25, 2019 | White Papers
Abstract The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are...
Mar 25, 2019 | Scientific Posters
Abstract Accidental wounds are one of the most common reasons for human visits to hospital emergency services. Healthy individuals normally heal accidental skin wounds in a rapid period if complications, such as infections, can be avoided. Aged individuals or...
Mar 14, 2019 | Scientific Posters
Abstract Phototoxicology safety testing in the miniature swine provides a unique opportunity for risk assessment because of demonstrated similarities to human cutaneous anatomy and physiology. In addition, the availability of several distinctive genetic origins...
