Mar 10, 2020 | Scientific Posters
Characterization of Glomerular Filtration Rate and Renal Blood Flow of Diabetic Miniature Swine Abstract People with type I diabetes (T1D) can have renal complications such as hyperfiltration and vascular restructuring that can potentially result in renal failure. The...
Apr 18, 2019 | White Papers
Orthopedic and Cartilage Models Introduction Osteoarthritis, cartilage and bone repair, and osteoporosis are research offerings at Sinclair Research. Sinclair Research offers 16 animal species as models for use in these protocols. Both non-regulatory and GLP studies,...
Mar 29, 2019 | White Papers
Sinclair – A Center of Excellence for Dermal Research Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal...
Mar 29, 2019 | Scientific Posters
Laser Induced Choroidal Neovascularization (CNV) as a Model of Age-related Macular Degeneration (AMD) in the Minipig Introduction Choroidal Neovascularization (CNV) is a known cause of Age-Related Macular Degeneration (AMD). Lucentis® (ranibuzumab) is a marketed...
Mar 29, 2019 | White Papers
Neurodegenerative Disease Models in Swine Introduction The most common neurodegenerative conditions in humans are Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy and ataxia-telangiectasia. These...
Mar 29, 2019 | White Papers
Vascular Studies in Minipigs Introduction Vascular surgical procedures and implantation of catheters and devices are common experimental procedures. Swine and especially miniature breeds are commonly used in experimental and preclinical trials for devices and...
Mar 29, 2019 | White Papers
Pain Control and Pain Research in Swine Abstract There are two aspects to pain research in swine. The one of primary interest to research veterinarians is the control of pain associated with experimental procedures and the second is the use of swine as an animal model...
Mar 28, 2019 | White Papers
Toxicology & Pharmacology Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs...
Mar 28, 2019 | White Papers
Catheterization of the Pancreatic Duct Abstract Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically...
Mar 28, 2019 | White Papers
Miniature Swine as Endo-urological and Urological Models Abstract The kidneys and urological plumbing system acts as the primary excretory system of the body and has great importance to maintain body fluid volumes and homeostasis or balance of the milieu intérieur...
