Orthopedic and Cartilage Models

Orthopedic and Cartilage Models

Orthopedic and Cartilage Models Introduction Osteoarthritis, cartilage and bone repair, and osteoporosis are research offerings at Sinclair Research. Sinclair Research offers 16 animal species as models for use in these protocols. Both non-regulatory and GLP studies,...
Sinclair – A Center of Excellence for Dermal Research

Sinclair – A Center of Excellence for Dermal Research

Sinclair – A Center of Excellence for Dermal Research Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal...
Neurodegenerative Disease Models in Swine

Neurodegenerative Disease Models in Swine

Neurodegenerative Disease Models in Swine Introduction The most common neurodegenerative conditions in humans are Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy and ataxia-telangiectasia. These...
Vascular Studies in Minipigs

Vascular Studies in Minipigs

Vascular Studies in Minipigs Introduction Vascular surgical procedures and implantation of catheters and devices are common experimental procedures. Swine and especially miniature breeds are commonly used in experimental and preclinical trials for devices and...
Pain Control and Pain Research in Swine

Pain Control and Pain Research in Swine

Pain Control and Pain Research in Swine Abstract There are two aspects to pain research in swine. The one of primary interest to research veterinarians is the control of pain associated with experimental procedures and the second is the use of swine as an animal model...
Toxicology & Pharmacology

Toxicology & Pharmacology

Toxicology & Pharmacology Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs...
Catheterization of the Pancreatic Duct

Catheterization of the Pancreatic Duct

Catheterization of the Pancreatic Duct Abstract Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically...
Miniature Swine as Endo-urological and Urological Models

Miniature Swine as Endo-urological and Urological Models

Miniature Swine as Endo-urological and Urological Models Abstract The kidneys and urological plumbing system acts as the primary excretory system of the body and has great importance to maintain body fluid volumes and homeostasis or balance of the milieu intérieur...