Orthopedic and Cartilage Models

Orthopedic and Cartilage Models

Introduction Osteoarthritis, cartilage and bone repair, and osteoporosis are research offerings at Sinclair Research. Sinclair Research offers 16 animal species as models for use in these protocols. Both non-regulatory and GLP studies, in large and small animal models...
Sinclair – A Center of Excellence for Dermal Research

Sinclair – A Center of Excellence for Dermal Research

Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal Research. This team works together to provide a wide range of...
Neurodegenerative Disease Models in Swine

Neurodegenerative Disease Models in Swine

Introduction The most common neurodegenerative conditions in humans are Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy and ataxia-telangiectasia. These conditions are caused by genetic, ageing,...
Vascular Studies in Minipigs

Vascular Studies in Minipigs

Introduction Vascular surgical procedures and implantation of catheters and devices are common experimental procedures. Swine and especially miniature breeds are commonly used in experimental and preclinical trials for devices and procedures. This includes such...
Pain Control and Pain Research in Swine

Pain Control and Pain Research in Swine

Abstract There are two aspects to pain research in swine. The one of primary interest to research veterinarians is the control of pain associated with experimental procedures and the second is the use of swine as an animal model to study new agents and methods of...
Toxicology & Pharmacology

Toxicology & Pharmacology

Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs and non human primates as the...
Catheterization of the Pancreatic Duct

Catheterization of the Pancreatic Duct

Abstract Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically manipulated. Total diversion of the...
Miniature Swine as Endo-urological and Urological Models

Miniature Swine as Endo-urological and Urological Models

Abstract The kidneys and urological plumbing system acts as the primary excretory system of the body and has great importance to maintain body fluid volumes and homeostasis or balance of the milieu intérieur (the environment within). In general, the pig has urological...
Hemorrhagic Shock Models in Swine

Hemorrhagic Shock Models in Swine

Introduction Swine have long been used as models for the study of hemorrhagic shock. In recent years there has been a resurgence of interest in the pathogenesis and treatment of hemorrhagic shock due to the ongoing conflicts associated with combating terrorism....