Apr 18, 2019 | White Papers
Introduction Osteoarthritis, cartilage and bone repair, and osteoporosis are research offerings at Sinclair Research. Sinclair Research offers 16 animal species as models for use in these protocols. Both non-regulatory and GLP studies, in large and small animal models...
Mar 29, 2019 | White Papers
Introduction Sinclair Research Center has put together a team of toxicologists, veterinarians, and technicians with background in dermal efficacy and toxicology to form a Center of Excellence for Dermal Research. This team works together to provide a wide range of...
Mar 29, 2019 | Scientific Posters
Introduction Choroidal Neovascularization (CNV) is a known cause of Age-Related Macular Degeneration (AMD). Lucentis® (ranibuzumab) is a marketed treatment for AMD, and is hypothesized to function by binding to vascular endothelial growth factors (VEGF) and preventing...
Mar 29, 2019 | White Papers
Introduction The most common neurodegenerative conditions in humans are Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, spinal muscular atrophy and ataxia-telangiectasia. These conditions are caused by genetic, ageing,...
Mar 29, 2019 | White Papers
Introduction Vascular surgical procedures and implantation of catheters and devices are common experimental procedures. Swine and especially miniature breeds are commonly used in experimental and preclinical trials for devices and procedures. This includes such...
Mar 29, 2019 | White Papers
Abstract There are two aspects to pain research in swine. The one of primary interest to research veterinarians is the control of pain associated with experimental procedures and the second is the use of swine as an animal model to study new agents and methods of...
Mar 28, 2019 | White Papers
Abstract There is an increased interest internationally in the use of minipigs as models in regulatory pharmacology and toxicology. This interest has come to the forefront because of the difficulties involved in procuring and using dogs and non human primates as the...
Mar 28, 2019 | White Papers
Abstract Catheterization of the pancreatic duct is indicated in studies in which sampling of the pancreatic exocrine secretions are required. The pancreas has a tendency towards developing pancreatitis when it is surgically manipulated. Total diversion of the...
Mar 28, 2019 | White Papers
Abstract The kidneys and urological plumbing system acts as the primary excretory system of the body and has great importance to maintain body fluid volumes and homeostasis or balance of the milieu intérieur (the environment within). In general, the pig has urological...
Mar 28, 2019 | White Papers
Introduction Swine have long been used as models for the study of hemorrhagic shock. In recent years there has been a resurgence of interest in the pathogenesis and treatment of hemorrhagic shock due to the ongoing conflicts associated with combating terrorism....
