Validation of the Use of a Telemetry Study to Measure Hemodynamic, Electrocardiographic and Respiratory Parameters in the Conscious Dog

 

Abstract:

Animal research remains a critical component to safety evaluation of candidate drugs, with telemetry providing insightful cardiorespiratory data. Safety pharmacology supports reducing animal numbers while optimizing study outcomes. Therefore, Beagle dogs were instrumented with Data Sciences International (DSI) implants (L11/L11R), and a structured Latin Square crossover design was used to ascertain the discrete effects of verapamil, dofetilide and doxapram.

Presented in conjunction with CorDynamics

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