Laser Induced Choroidal Neovascularization (CNV) as a Model of Age-related Macular Degeneration (AMD) in the Minipig
Choroidal Neovascularization (CNV) is a known cause of Age-Related Macular Degeneration (AMD). Lucentis® (ranibuzumab) is a marketed treatment for AMD, and is hypothesized to function by binding to vascular endothelial growth factors (VEGF) and preventing aberrant vascular growth. Ocular similarities between humans and the minipig make it a useful model for ocular therapies, and this study aimed to validate the minipig model of laser induced CNV.
Stricker-Krongrad, A., Leigh, H., Harvey, R.M., Jones, M.R., Tellez, A., Stanley, J., Wicks, J., Bouchard G.F.