Electroretinography (ERG) of C57BL/6 and NIH III Mice

Abstract

Electroretinography(ERG) is a unique tool for measuring the electrical potentials of the retina and evaluating in-development drug products for potential ocular effects, such as induced retinal degeneration. The mouse has become a popular model for the study of retinal degeneration, and new generation electrodes have been used successfully to obtain electroretinograms from mice as young as 14 days. The C57BL/6 mouse (female, 7-8 weeks, 13-17g) and NIH III strain of nude mouse (male, aged 6-8 weeks, 19-28g) were used in this baseline study of niaveanimals. We measured ERGs of 5 C57BL/6 and 59 NIH III untreated mice using the DiagnosysLLC, EspionE² System. All C57BL/6 mice had acceptable ERG recordings while 12 (20%) of the NIH III mice had flat-line recordings, which might be a result of retinal degeneration. Mean values for retinal ERG potentials of the NIH III and C57BL/6 are presented below. These data offer baseline ERG measurements for the NIH III and C57BL/6 strains of mice.

Authors

Leigh, H., Blair, E., Liu, J., Brown, L., Bouchard, G.F.

Download this Scientific Poster

Upcoming Webinar

Join Cordynamics' Michael R. Gralinski on July 8th for this live webinar.

SAVE YOUR SEAT

You have Successfully Subscribed!