Preclinical pharmacology, composed of determining pharmacokinetics (PK) and efficacy in an animal model, is vital to drug development. Researchers report that the PK of a drug governs efficacy and toxicity, two main considerations of drug candidates. Although in vitro data are helpful, the dynamics unique to living animal systems and processes acting in unison support the need for in vivo research. Sinclair Research offers in vivo drug metabolism and pharmacokinetic (DMPK), biotransformation, and metabolism studies essential for understanding PK profiles. If warranted, we can also determine if a metabolite of the parent drug is more efficacious, safer, and has a better PK profile than the parent. Sinclair performs drug discovery and formulation pharmacology on miniature swine, canines, NHPs, and rodents. We also offer many animal models for preclinical pharmacology, such as immunosuppressed mice and diabetic miniature swine.

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