Normal Physiological and Pathological Values for the Sinclair Miniature Swine

Authors

Brocksmith, D., Liu, J., Stricker-Krongrad, A., Bouchard, G.F.

Abstract

The Sinclair miniature swine (SMS) is the oldest strain of miniature swine developed for research; it is one of the smallest as well. In an effort to generate a database of baseline information about the normal physiological status of the SMS, information was retrospectively collected from control animals in various toxicology studies, as well as from studies designed solely to collect baseline information. We are reporting physiological data from normal intact and naïve juvenile and young adult SMS of both genders, including weight and body measurements, hematology, serum chemistry, coagulation profile, urinalysis, ECG rhythm and segment intervals, and organ weights including the brain and pituitary gland, thoracic organs, reproductive organs, and abdominal organs excluding stomach, pancreas, and intestines. Miniature swine overall are increasingly recognized as a non-rodent model in regulatory toxicology and dermal toxicology. The similarities of their cardiovascular, renal, and digestive systems to those of humans make them a suitable animal to model the human counterpart; they are also amenable to all routes of compound administration. Additional attractive traits that make them a good substitute to model humans are that they are omnivorous, easy to handle, prone to obesity, and will develop atherosclerosis and dyslipidemia when fed a high fat diet. The resultant data from this retrospective study will benefit the SMS as one of the non-rodent species in research by providing baseline information with which to correctly interpret regulatory toxicity and other testing results.

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