Minipigs: Applications in Toxicology

Authors

Brown, L.D., Stricker-Krongrad, A., Bouchard, G.F.

Abstract

Minipigs are accepted models for a variety of drug preclinical and nonregulatory toxicology
studies. Acute, subchronic and chronic studies are possible using all routes of administration.
Minipigs have distinct size advantages over domestic pigs. There exist some minor limitations
with minipigs, but for the most part they offer well correlated models to humans for dermal
and systemic toxicology assessments. Phototoxicology and reproductive toxicology usage is
expanding. Minipig size, anatomy, physiology, metabolism, and genetics generally correlate well
to human factors. The minipig makes an appropriate model for toxicology.

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