Minipig Translational Research Models
M. Michael Swindle, DVM, Professor Emeritus, Department of Comparative Medicine, Medical University of SC, Charleston, SC; Biomedical and Surgical Consultant
Miniature swine have been utilized as translational research models with outcomes in high concordance with humans in a variety of systems. Much of the data justifying the minipig models has been published in books and review manuscripts. Summary publications of some of the major models have also been published online. Major systems utilized in these types of studies are: cardiovascular, dermal, digestive, urogenital, neurologic, ophthalmic, and musculoskeletal. This manuscript will discuss areas where swine have been demonstrated to be translational models with direct application to humans.