Metabolic Disease

Metabolic disease and diabetes are ever-growing medical problems in today’s society. Pathophysiological and metabolic changes associated with the onset and development of diabetes mellitus can be modeled in laboratory animals by chemical induction, genetic intervention, or dietary modification. Chemically-induced Type I diabetic miniature swine models have been in use at Sinclair Research for over 10 years. Our staff is very experienced in the area of miniature swine diabetes induction and evaluation of candidate therapeutics. We continually maintain a large herd of diabetic Yucatan miniature swine as a resource for studies. Sinclair has expanded its diabetes and metabolic disease programs, developing other clinically-relevant models in multiple species such as rodents, canines, and NHPs. Glucose tolerance, insulin resistance testing, and insulin potency testing are routinely included in studies.

Why partner with Sinclair Research?

As one of the largest nonclinical CROs in North America, Sinclair Research’s scientific and technical expertise can provide you with the Metabolic Disease research services you need, the data you expect, and the customer experience you deserve! Contact our team to discuss your upcoming research and meet with our scientific experts to discuss how to reach your next development milestone.

Our Metabolic Disease Services include:

Relevant Animal Models

Spontaneous/Genetic Models:
  • Obesity
  • Metabolic syndrome
  • Hypertension
  • Type II diabetes
Induced Models:
  • Specialized diets
  • Chemicals
  • Surgical
  • Type I & II diabetes

Available Clinical Assessments

  • DEXA analysis
  • Urine chemistry
  • Food and water consumption
  • Serum chemistry
  • Lipid profiles
  • Liver function tests
  • Kidney function profile
  • Hormones and biomarkers
  • Glucose disposal (oGTT and ivGTT)
  • Hyperinsulinemic-glycemic clamp

Talk to an expert!