Dilated Cardiomyopathy and Ischemic Heart Failure Models in Pigs
M. Michael Swindle, DVM, Department of Comparative Medicine, Medical University of SC, Charleston, SC 29425
A previous manuscript on this website, SURGICALLY PRODUCED VOLUME AND PRESSURE OVERLOAD HEART FAILURE MODELS IN SWINE, discussed heart failure models that could be produced in swine using selected surgical techniques. Pressure overload hypertrophy is produced by surgical banding of the great vessels of the heart and leads to concentric hypertrophy of the heart. Volume overload hypertrophy of the heart is produced by surgically creating valvular regurgitation or an arteriovenous fistula leading to eccentric hypertrophy of the heart. These conditions lead to different types of heart failure which are reviewed in the previous manuscript. The manuscript also describes the anatomy and physiology of the porcine heart.