Dermal Studies

Sinclair Research is a center of excellence for dermal research with a broad range of capabilities, expertise, and best practices. Sinclair personnel are experts in dermal toxicity testing, conducting GLP-compliant dermal and transdermal toxicology and safety studies. In addition to toxicology, Sinclair supports a wide range of drug metabolism and pharmacokinetic (DMPK) studies, and efficacy studies including wound healing and inflammatory studies in an FDA-recommended model, the miniature swine. The Sinclair Research team has experience with all conventional routes of compound administration, including transdermal (passive and active), dermal applications (ointments, creams, lotions) and dermal application specialized devices.

We are used to working with all commonly used research lineages of miniature swine, namely the Hanford, Gottingen, Sinclair, and Yucatan. The Hanford miniature swine, which has white skin, has been used for over 20 years as a model for dermal studies. Sinclair has developed a white hairless Yucatan miniature swine breed for dermal absorption, irritation, and photosensitivity studies. The Sinclair miniature swine has also been selected for white skin and is smaller than either the Yucatan or Hanford lineages, which also makes them appropriate models for dermal studies.

In addition to miniature swine, Sinclair offers dermal studies in a number of other species, including mice, rats, rabbits, guinea pigs, dogs and non-human primates.

Why partner with Sinclair Research?

As one of the largest nonclinical CROs in North America, Sinclair Research’s scientific and technical expertise can provide you with the dermal research services you need, the data you expect, and the customer experience you deserve! Contact our team to discuss your upcoming research and meet with our scientific experts to discuss how to reach your next development milestone.

Our Dermal Research services include:

  • Dermal toxicity testing
  • Acute, short-term ( 7 to 28-day), subchronic ( 90-day), or chronic exposure durations
  • Single or repeat dose, occluded or non-occluded administration site
  • Passive and active (iontophoretic) dermal/transdermal patch administration
  • Dermal evaluation of irritation, sensitization, and local tolerance
  • Phototoxicity and photoallergy models
  • Standard toxicology endpoints: clinical observations, clinical pathology, ECG, opthalmology, histopathology
  • Dermal drug metabolism and pharmacokinetic (DMPK) studies
  • Pharmacokinetics and toxicokinetics for dermal/transdermal routes of administration
  • Cross-contamination prevention: custom equipment for dermal studies
  • Dedicated dermal study team for scoring (Draise, Magnuson, and Kligman grading) and photography.
  • Custom large animal enclosures for dermal studies, utilizing stainless steel full barriers.
  • Dose preparation

Other skin models:

  • Full-thickness and partial thickness dermal wounds, skin barrier interruption by scarification and tape stripping of the stratum corneum
  • Skin allergy, atopy, depigmentation

Talk to an expert!