Interventional Cardiovascular Procedures

Interventional Cardiovascular Procedures

Introduction Swine have been one of the primary animal models for preclinical testing of catheter introduced devices into the cardiovascular system. This publication reviews the models and technical procedures that are commonly employed in these techniques and...
Interesting Facts About Miniature Swine & Bone Research

Interesting Facts About Miniature Swine & Bone Research

Introduction Mature, intact miniature pigs showed rapid bone loss during the first 7 months of prednisolone treatment, indicating that minipigs show promise as models for steroidinduced osteoporosis. (Stampa, ScholzAhrens, et. al., 1999) Authors M. Michael Swindle,...
Diabetes Mellitus and the Cardiometabolic Syndrome in Swine

Diabetes Mellitus and the Cardiometabolic Syndrome in Swine

Introduction Diabetes mellitus is occurring in epidemic proportions worldwide and it is estimated by the World Health Organization (WHO) and the American Diabetes Association (ADA)2 that 300 million persons will have the disease by 2025. Currently WHO and ADA classify...
Diabetes in Miniature Swine

Diabetes in Miniature Swine

Introduction Diabetes mellitus is the most common endocrine disorder of humans and Type 2 diabetes (T2D) is currently the 6th leading cause of death. Diabetes is characterized by abnormalities of carbohydrate and lipid metabolism and long-term complications including...
Developmental Guidelines in Swine

Developmental Guidelines in Swine

Introduction Frequently there is a need to understand the developmental stage of the animal as a whole, as well as the state of maturity of individual tissues and/or individual organs in swine when designing a research protocol. This is important both in comparing the...
White Hairless Miniature Swine Model for Dermal Studies

White Hairless Miniature Swine Model for Dermal Studies

Introduction The miniature swine is a well recognized animal model of dermal toxicology, transdermal drug delivery and woundhealing. In fact, staff members of the USFDA have recommended the use of miniature swine for dermal toxicological research and, until recently,...
Comparative Anatomy of the Pig

Comparative Anatomy of the Pig

Introduction With the increasing use of swine as models in biomedical and surgical research, investigators have encountered difficulty with the species because of physiologic and anatomic variations from more traditional large animal models, such as the dog. The...