Sinclair Miniature Swine Osteopenia Model

Introduction Osteoporosis is a serious public health concern that affects almost 28 million people in the United States.Postmenopausal osteoporosis is a chronic, disabling disease of high prevalence in elderly people, particularlywomen. Its prevalence is becoming very...

Cartilage and Bone Models in Swine

Authors M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC Abstract Swine have not been utilized as one of the primary models for orthopedic procedures due to the massive size of...

Minipig Translational Research Models

Authors M. Michael Swindle, DVM, Professor Emeritus, Department of Comparative Medicine, Medical University of SC, Charleston, SC; Biomedical and Surgical Consultant Abstract Miniature swine have been utilized as translational research models with outcomes in high...

Miniature Swine in Osteoporosis Research

Introduction Miniature swine have been used as a model of osteopenia at Sinclair Research Center since 1989. Miniature swine have a lot to offer to the field of osteoporosis. The following list is a summary of the positive attributes of miniature swine for...

Ventricular Septal Defect (VSD) in Yucatan Miniature Swine

Authors M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC Introduction By selective breeding techniques a heritable ventricular septal defect (VSD) has been produced in Yucatan...

Trauma Models in Swine

Authors M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of SC, Charleston, SC 29425 Introduction There has been an increased interest in the development of animal models of trauma largely due to worldwide...