Apr 6, 2020 | White Papers
Animal welfare considerations are important to the conduct of good research. A generally accepted tenet is that animals which are maintained in a non-stressful environment will be more physiologically stable and therefore provide more reliable data in an experiment....
Jun 3, 2019 | White Papers
Introduction Osteoporosis is a serious public health concern that affects almost 28 million people in the United States. Postmenopausal osteoporosis is a chronic, disabling disease of high prevalence in elderly people, particularly women. Its prevalence is becoming...
May 3, 2019 | White Papers
Introduction Swine have not been utilized as one of the primary models for orthopedic procedures due to the massive size of the bones and musculature. However, over the past two decades there has been an increased interest in the development of models for the...
May 3, 2019 | White Papers
Abstract Miniature swine have been utilized as translational research models with outcomes in high concordance with humans in a variety of systems. Much of the data justifying the minipig models has been published in books and review manuscripts. Summary publications...
May 3, 2019 | White Papers
Introduction Miniature swine have been used as a model of osteopenia at Sinclair Research Center since 1989. Miniature swine have a lot to offer to the field of osteoporosis. The following list is a summary of the positive attributes of miniature swine for...
May 3, 2019 | White Papers
Introduction By selective breeding techniques a heritable ventricular septal defect (VSD) has been produced in Yucatan miniature swine which can be utilized as an animal model of the condition in humans. The model shares many important similarities to human VSD....
May 3, 2019 | White Papers
Introduction There has been an increased interest in the development of animal models of trauma largely due to worldwide conflicts involving terrorism. Many governmental agencies have developed funding mechanisms for the treatment of major trauma as well as...
May 3, 2019 | White Papers
Introduction Human melanoma is the fastest growing cancer currently in USA and worldwide. Melanoma accounts for 5% of all skin cancers but 71% of all skin cancer deaths. The risk for melanoma has steadly increased since 1935 when the risk was 1:1,500. Today one in 74...
May 3, 2019 | White Papers
Introduction Sinclair personnel are experts in conducting the dermal/transdermal safety studies (GLP and non-GLP) needed for registration of a dermal or transdermal test article/device, either 505 (b)(1) or 505 (b)(2) pathways. Download this Scientific White...
May 3, 2019 | White Papers
Introduction Pain assessment postoperatively should be performed in a systematic fashion to determine if swine require the administration of systemic analgesics. Postoperative monitoring involves making the following observations: Condition of incision...
