White Hairless Miniature Swine for Dermal Studies
Sinclair Bio Resources is proud to have a unique dermal animal model available in the white ‘hairless’ Yucatan miniature swine. The white hairless skin facilitates evaluation for dermal irritation, such as the Draize test for erythema and edema, with minimal to no shaving required. A subset of this lineage has both light gray (melanotic) and white (amelanotic) skin areas, offering the opportunity for side-by-side comparisons of candidate drugs whose properties may be affected by skin melanin content or where safety assessment is needed on both categories of skin. This white hairless model is gaining popularity for dermal pharmacokinetic, toxicokinetic, and wound healing studies.
There are many benefits to using miniature swine for dermal studies. Aside from anatomic similarities, they are equivalent to primates for percutaneous absorption studies and have similar lipid biophysical properties, epidermal turnover kinetics, and carbohydrate metabolism in the skin. They possess sufficient body weight to tolerate prolonged topical administration of potent drugs, unlike smaller lab animal species. Their skin is tightly adhered and is anatomically, physiologically, biochemically, and immunologically similar to human skin. Their skin additionally mirrors human skin by having a sparse haircoat and a relatively thick epidermis; the arrangement of dermal collagen and elastic fibers is comparable as well.
The miniature swine is a well-recognized animal model of dermal toxicology, transdermal drug delivery, and wound healing; their use has even been recommended by the Food and Drug Administration for dermal toxicological research.