Metabolism & Pharmacokinetics

Sinclair Research Center provides GLP-compliant In Vivo DMPK services from discovery through development in our state-of-the-art facility near Columbia, Missouri.

Drug Discovery/Drug Development

  • Pharmacodynamics
  • Blood, Plasma, and Tissue Concentration
  • Biliary Excretion (mouse, rat, dog)
  • Volatile Collection
  • QWBA (In Vivo at Sinclair, Sectioning and Analysis Subcontracted)
  • Metabolic Caging for Multiple Species (rodent, cat, dog, goat, swine)

Pharmacokinetics/Toxicokinetics

  • Pharmacokinetics/Toxicokinetics
  • Bioequivalence & Bioavailability
  • Single or Multiple Dosing (In-life)
  • PK/TK Analysis
  • IVGTT, OGTT, & Glucose Clamps
  • Meal Interference/Glycemic Challenge

Routes of Dose Administration

  • Parenteral (IV/SC/IM/IP)
  • Ocular
  • IV Infusion
  • Auricular
  • Intranasal
  • Rectal/Intravaginal
  • Dermal/Intradermal/Transdermal patch
  • Oral (gavage/liquid/ tablet/capsule)
  • Vascular Access Ports (VAP)
  • Intracoronary/Intraventricular (percutaneous access)
  • Rodent Vascular and Non-Vascular Cannulas

Test Facility

  • AAALAC Accredited Facility Since 1995
  • High Capacity for Small and Large Animals
  • Rodents
  • Canines
  • Miniature Swine (Sinclair, Yucatan, Hanford)
  • Non-Human Primates
  • Rabbits
  • Felines
  • Housing for Other Species Available (goat, sheep, horses)

Analytical Support – Alliance Partner Service

  • Discovery and GLP-compliant bioanalytical chemistry services
  • Sample Analysis-Routine Bioanalysis
    • Quantitative Analysis of Drug and Metabolites in Biological Matrices
    • Dose Formulation Analysis, Interference Testing
  • Analytical Method Development, Validation (Full, Cross, & Partial), Method Transfer & Sample Analysis (LC-MS/MS, HPLC, ICP-MS, and Immunoblots)
  • Dose Analysis (Radiochemical Purity, Specific Activity)
  • Metabolite Characterization & Identification
  • Immunoassays
    • ELISA
    • Method Development and Validation, Routine Sample Analysis
  • SRC can also work with the Sponsor’s in-house analytical laboratory or with a Sponsor designated analytical laboratory in support of the studies.
Additional Resources:
 Literature Sheet

Please contact us at:
573 387 4400
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