Animal Models

Sinclair has a strong commitment to supporting research and development programs of the biopharmaceutical industry. Over the past ten years, Sinclair has contributed to the development of large animal models of osteopenia and other animal models.

Large Animal Model Production for Your Research Program

Sinclair specializes in the production of animal models. In fact, Sinclair is the only private company primarily involved in large animal model development. Sinclair has contributed to and is experienced in a number of animal models available to our clients, namely:

• Spontaneous Regressing Malignant Melanoma
• White Hairless Miniature Swine for Dermal Studies
• Spontaneous Ventricular Septal Defect (VSD)
• MHC Defined Lineages for Transplantation
• Diabetes Type 1 and 2
• Obesity/Weight Management
• Osteoporosis (4 models)
• Atherosclerosis
• Surgical Modeling
• Orthopedic Modeling

Sinclair continues to offer complete Support for the animal sales. Sinclair is very experienced in pre-shipping alterations, which are performed in the spirit of GLP. Common pre-shipping alterations include: vascular access ports placement, high cholesterol diet feeding, diabetes induction, test article administration, biopsies collection for autotransplantation, etc. Furthermore, Sinclair is a full service CRO, offering small and large animal in-vivo pharmacology, toxicology, and medical device research in a regulatory environment. Sinclair also provides an array of bio-samples in rodents, cats, dogs, miniature swine, goats, and sheep.

Sinclair complies with a number of agencies. We are USDA licensed as a breeder (43-A-2499) and research facility (43-R-0109). We are AAALAC accredited and GLP compliant. The animal care and veterinary program is in compliance with the Guide for the Care and Use of Laboratory Animals. Sinclair has an Assurance Statement filed with PHS.